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Development of inapparent dengue associated with increased antibody levels to Aedes aegypti salivary proteins: a longitudinal dengue cohort in Cambodia

  1. Author:
    Manning, Jessica E [ORCID]
    Chea, Sophana
    Parker, Daniel M
    Bohl, Jennifer A
    Lay, Sreyngim
    Mateja,Allyson
    Man, Somnang
    Nhek, Sreynik
    Ponce, Aiyana
    Sreng, Sokunthea
    Kong, Dara
    Kimsan, Soun
    Meneses, Claudio
    Fay, Michael P
    Suon, Seila
    Huy, Rekol
    Lon, Chanthap
    Leang, Rithea
    Oliveira, Fabiano [ORCID]

  2. Author Address

    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Phnom Penh, Cambodia., National Center for Parasitology, Entomology, and Malaria Control, Ministry of Health, Phnom Penh Cambodia., University of California, Irvine, California, USA., Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., National Dengue Control Program, Ministry of Health, Phnom Penh, Cambodia., Biostatistics Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.,
    1. Year: 2021
    2. Date: Oct 27
    3. Epub Date: 2021 10 27
  2. Journal: The Journal of Infectious Diseases
  4. Type of Article: Article
  1. Abstract:

    We established the first prospective cohort to understand how infection with dengue virus is influenced by vector-specific determinants like humoral immunity to Aedes aegypti salivary proteins. Children aged two to nine years old enrolled in the PAGODAS (Pediatric Assessment Group of Dengue and Aedes Saliva) cohort with informed consent by their guardians. Children were followed semi-annually for antibodies to dengue and to proteins in Ae. aegypti salivary gland homogenate using enzyme-linked immunosorbent assays and dengue-specific neutralization titers. Children presented with fever at any time for dengue testing. From July 13 to August 30, 2018, we enrolled 771 children. At baseline, 22% (173/770) had evidence of neutralizing antibodies to one or more dengue serotypes. By April 2020, 51 children had symptomatic dengue while 148 dengue-naïve children had inapparent dengue defined by neutralization assays. In a multivariate model, individuals with higher antibodies to Ae. aegypti salivary proteins were 1.5x more likely to have dengue infection (HR 1.47 95% CI 1.05-2.06; p=0.02), particularly individuals with inapparent dengue (HR 1.64 95% CI 1.12-2.41; p=0.01). High levels of seropositivity to Ae. aegypti salivary proteins are associated with future development of dengue infection, primarily inapparent, in dengue-naïve Cambodian children. Published by Oxford University Press for the Infectious Diseases Society of America 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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  2. DOI: 10.1093/infdis/jiab541
  3. PMID: 34718636
  4. PII : 6412508

Library Notes

  1. Fiscal Year: FY2021-2022
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