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HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria

  1. Author:
    Kruzel-Davila, Etty
    Sankofi, Barbara Mensah
    Kubi Amos-Abanyie, Ernestine
    Ghansah, Anita
    Nyarko, Alexander
    Agyemang, Seth
    Awandare, Gordon A
    Szwarcwort-Cohen, Moran
    Reiner-Benaim, Anat
    Hijazi, Basem
    Ulasi, Ifeoma
    Raji, Yemi Raheem
    Boima, Vincent
    Osafo, Charlotte
    May Adabayeri, Victoria
    Matekole, Michael
    Olanrewaju, Timothy O
    Ajayi, Samuel
    Mamven, Manmak
    Antwi, Sampson
    Ademola, Adebowale D
    Plange-Rhule, Jacob
    Arogundade, Fatiu
    Akyaw, Priscilla Abena
    Winkler,Cheryl
    Salako, Babatunde L
    Ojo, Akinlolu
    Skorecki, Karl
    Adu, Dwomoa

  2. Author Address

    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel., Nephrology Department, Rambam Health Care Campus, Haifa, Israel., College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana., University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana., Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Department of Medicine, College of Health Sciences University of Nigeria, Enugu, Nigeria., Department of Medicine, University of Ibadan, Ibadan, Nigeria., Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Department of Medicine, University of Abuja, Abuja, Nigeria., Obafemi Awolowo University, Ile-Ife, Nigeria., Department of Medicine, Frederick National Laboratory for Cancer Research (NIH), Frederick, MD, United States., School of Medicine, University of Kansas Medical Center, Kansas City, KS, United States.,
    1. Year: 2021
    2. Date: Aug 27
    3. Epub Date: 2021 Aug 27
  2. Journal: Frontiers in Medicine
    1. 8
    2. Pages: 718300
  4. Type of Article: Article
  5. Article Number: 718300
  6. ISSN: 2296-858X
  1. Abstract:

    Variants in the Apolipoprotein L1 (APOL1) gene (G1-rs60910145, rs73885319, G2-rs71785313) are common in Africans and in individuals of recent African ancestry and are associated with an increased risk of non-diabetic chronic kidney disease (CKD) and in particular of HIV associated nephropathy (HIVAN). In light of the significantly increased risk of HIVAN in carriers of two APOL1 risk alleles, a role in HIV infectivity has been postulated in the mechanism of APOL1 associated kidney disease. Herein, we aim to explore the association between HIV viremia and APOL1 genotype. In addition, we investigated interaction between BK and JC viruria, CKD and HIV viremia. A total of 199 persons living with HIV/AIDS (comprising 82 CKD cases and 117 controls) from among the participants in the ongoing Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network case control study have been recruited. The two APOL1 renal risk alleles (RRA) genotypes were associated with a higher risk of CKD (OR 12.6, 95% CI 3.89-40.8, p < 0.0001). Even a single APOL1 RRA was associated with CKD risk (OR 4.42, 95% CI 1.49-13.15, p = 0.007). The 2 APOL1 RRA genotypes were associated with an increased probability of having HIV viremia (OR 2.37 95% CI 1.0-5.63, p = 0.05). HIV viremia was associated with increased CKD risk (OR 7.45, 95% CI 1.66-33.35, P = 0.009) and with a significant reduction of JC virus urine shedding (OR 0.35, 95% CI 0.12-0.98, p = 0.046). In contrast to prior studies, JC viruria was not associated with CKD but was restricted in patients with HIV viremia, regardless of CKD status. These findings suggest a role of APOL1 variants in HIV infectivity and emphasize that JC viruria can serve as biomarker for innate immune system activation. Copyright © 2021 Kruzel-Davila, Sankofi, Kubi Amos-Abanyie, Ghansah, Nyarko, Agyemang, Awandare, Szwarcwort-Cohen, Reiner-Benaim, Hijazi, Ulasi, Raji, Boima, Osafo, May Adabayeri, Matekole, Olanrewaju, Ajayi, Mamven, Antwi, Ademola, Plange-Rhule, Arogundade, Akyaw, Winkler, Salako, Ojo, Skorecki and Adu.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fmed.2021.718300
  3. PMID: 34513880
  4. PMCID: PMC8429812
  5. View record in Web of Science®
  6. WOS: 000698479600001

Library Notes

  1. Fiscal Year: FY2020-2021
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