Skip NavigationSkip to Content
Return Return to Search Results

Material strategies and considerations for serologic testing of global infectious diseases

  1. Author:
    Manning, Jessica E.
    Duffy, Patrick E.
    Esposito,Dom
    Sadtler, Kaitlyn

  2. Author Address

    Natl Inst Hlth, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Phnom Penh, Cambodia.NIAID, Lab Malaria Immunol & Vaccinol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Frederick Natl Lab Canc Res, Prot Express Lab, NCI RAS Initiat, Frederick, MD USA.Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD 20892 USA.
    1. Year: 2021
    2. Date: Sep 13
    3. Epub Date: 2021 09 13
  2. Journal: MRS Bulletin
  3. Springer Heidelberg
    1. 46
    2. Pages: 1-5
  5. Type of Article: Review
  6. ISSN: 0883-7694
  1. Abstract:

    The SARS-CoV-2 pandemic has brought to light multiple considerations when approaching infectious diseases on the global level. These range from diagnostic platforms, to therapeutics, and prevention agents. In this article, we focus on the engineering platforms and considerations when applying serologic assays to multiple geographic locations, climates with varying endemic virus repertoires, and different laboratory and clinical resource settings. Serologic assays detect antibodies that react against viral proteins, suggesting prior infection and correlative of an increased likelihood of immunity to future infection. As these assays are focused on the human immune response to a pathogen, and humans are variable, there are a number of important engineering steps to optimize assay performance, from sample collection, to assay execution and data analysis. Moving forward, a global approach to infectious disease detection and prevention is necessary to prevent the spread of future viruses with pandemic potential.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1557/s43577-021-00167-4
  3. PMID: 34539056
  4. PMCID: PMC8437333
  5. View record in Web of Science®
  6. WOS: 000695416400001

Library Notes

  1. Fiscal Year: FY2020-2021
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel