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Elevations in serum soluble interleukin-2 receptor levels predict relapse in patients with hairy cell leukemia

  1. Author:
    Arun, B.
    Curti, B. D.
    Longo, D. L.
    Stevens, D.
    Alvord, W. G.
    Gause, B. L.
    Watson, T.
    Kopp, W. C.
    Janik, J. E.

  2. Author Address

    Longo DL NIA, NIH, Gerontol Res Ctr Box 9,5600 Nathan Shock Dr Baltimore, MD 21224 USA NIA, NIH, Gerontol Res Ctr Baltimore, MD 21224 USA Georgetown Univ, Vincent T Lombardi Canc Res Ctr Washington, DC USA NCI, Clin Res Branch, Biol Response Modifiers Program, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA NCI, Clin Serv Program, SAIC Frederick, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA NCI, Data Management Serv Inc, SAIC Frederick, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA
    1. Year: 2000
    2. Date: JAN-FEB
  2. Journal: Cancer Journal from Scientific American
    1. 6
    2. 1
    3. Pages: 21-24
  4. Type of Article: Article
  1. Abstract:

    PURPOSE Interferon-alfa, 2'-deoxycoformycin, and 2-chlorodeoxy-adenosine (2-CdA) are effective in the management of patients with hairy cell leukemia These agents produce remissions in most patients, but relapses occur with ail three drugs. The optimal means to follow patients for relapse after treatment has not been determined a METHODS We retrospectively examined serial serum soluble interleukin-2 receptor levels (sIL-2R) and absolute granulocyte counts in eight patients with relapsed hairy cell leukemia. All were treated with 2-CdA at the time of relapse. Serum samples were available at 3- to 6-month intervals from 5 to 9 years before relapse and 2-CdA treatment. RESULTS sIL-2R levels increase only in patients who go on to relapse. sIL-2R levels doubled a mean of 17.1 months (range, 4-36 months) before absolute granulocyte count decreased by 50%, DISCUSSION Demonstration of a rising serum sIL-2R level in patients with hairy cell leukemia identified those,vith an increased risk of relapse who need more frequent observation than patients who maintain a stable sIL-2R level. Early intervention may ameliorate the toxicity of salvage therapy because disease-related neutropenia may be anticipated. [References: 16]

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