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Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case

  1. Author:
    Vannella, Kevin M
    Oguz,Cihan
    Stein, Sydney R
    Pittaluga, Stefania
    Dikoglu, Esra
    Kanwal, Arjun
    Ramelli, Sabrina C
    Briese, Thomas
    Su, Ling
    Wu, Xiaolin
    Ramos-Benitez, Marcos J
    Perez-Valencia, Luis J
    Babyak, Ashley
    Cha, Nu Ri
    Chung, Joon-Yong
    Ylaya, Kris
    Madathil, Ronson J
    Saharia, Kapil K
    Scalea, Thomas M
    Tran, Quincy K
    Herr, Daniel L
    Kleiner, David E
    Hewitt, Stephen M
    Notarangelo, Luigi D
    Grazioli, Alison
    Chertow, Daniel S

  2. Author Address

    Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States., Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., National Institute of Allergy and Infectious Diseases Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States., Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States., Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Division of Cardiology, Westchester Medical Center, Valhalla, NY, United States., Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, United States., Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States., Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, United States., Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States., Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, United States., Department of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, United States., Department of Surgery, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States., Department of Emergency Medicine, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States., Department of Medicine, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Kidney Diseases Branch, Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.,
    1. Year: 2021
    2. Date: Dec 9
    3. Epub Date: 2021 12 09
  2. Journal: Frontiers in Immunology
    1. 12
    2. Pages: 779026
  4. Type of Article: Article
  5. Article Number: 779026
  6. ISSN: 1664-3224
  1. Abstract:

    A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis. Copyright © 2021 Vannella, Oguz, Stein, Pittaluga, Dikoglu, Kanwal, Ramelli, Briese, Su, Wu, Ramos-Benitez, Perez-Valencia, Babyak, Cha, Chung, Ylaya, Madathil, Saharia, Scalea, Tran, Herr, Kleiner, Hewitt, Notarangelo, Grazioli and Chertow.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fimmu.2021.779026
  3. PMID: 34956207
  4. PMCID: PMC8695925
  5. View record in Web of Science®
  6. WOS: 000738321400001

Library Notes

  1. Open Access Publication
  2. Fiscal Year: FY2021-2022
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