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PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity

  1. Author:
    He, Sijia
    Waheed, Abdul A.
    Hetrick, Brian
    Dabbagh, Deemah
    Akhrymuk, Ivan V.
    Kehn-Hall, Kylene
    Freed, Eric O.
    Wu, Yuntao

  2. Author Address

    George Mason Univ, Sch Syst Biol, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA.NCI, Virus Cell Interact Sect, HIV Dynam & Replicat Program, Ctr Canc Res, Ft Detrick, MD 21702 USA.Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA.
    1. Year: 2020
    2. Date: Dec 30
  2. Journal: Viruses
  3. MDPI,
    1. 13
    2. 1
  5. Type of Article: Article
  6. Article Number: ARTN 46
  7. ISSN: 1999-4915
  1. Abstract:

    P-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 has been identified as an interferon-gamma (INF-gamma)-regulated factor that restricts HIV-1 infectivity, and has recently been found to possess broad-spectrum antiviral activities. Here we report that the expression of PSGL-1 in virus-producing cells impairs the incorporation of SARS-CoV and SARS-CoV-2 spike (S) glycoproteins into pseudovirions and blocks pseudovirus attachment and infection of target cells. These findings suggest that PSGL-1 may potentially inhibit coronavirus replication in PSGL-1(+) cells

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External Sources

  1. View Full Text
  2. DOI: 10.3390/v13010046
  3. PMID: 33396594
  4. PMCID: PMC7824426
  5. View record in Web of Science®
  6. WOS: 000610813400001

Library Notes

  1. Fiscal Year: FY2020-2021
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