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Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers

  1. Author:
    Goguet, Emilie [ORCID]
    Powers,John
    Olsen, Cara H [ORCID]
    Tribble, David R [ORCID]
    Davies, Julian
    Illinik, Luca
    Jackson-Thompson, Belinda M
    Hollis-Perry, Monique
    Maiolatesi, Santina E
    Pollett, Simon
    Duplessis, Christopher A
    Wang, Gregory
    Ramsey, Kathleen F
    Reyes, Anatalio E
    Alcorta, Yolanda
    Wong, Mimi A
    Ortega, Orlando
    Parmelee, Edward
    Lindrose, Alyssa R [ORCID]
    Moser, Matthew
    Samuels, Emily C
    Coggins, Si'Ana A
    Graydon, Elizabeth
    Robinson, Sara
    Campbell, Wesley
    Malloy, Allison M W
    Voegtly, Logan J
    Arnold, Catherine E
    Cer, Regina Z
    Malagon, Francisco
    Bishop-Lilly, Kimberly A [ORCID]
    Burgess, Timothy H
    Broder, Christopher C
    Laing, Eric D
    Mitre, Edward [ORCID]

  2. Author Address

    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Department of Preventive Medicine & Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Infectious Diseases Clinical Research Program, Department of Preventive Medicine & Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA., General Dynamics Information Technology, Falls Church, Virginia, USA., Division of Infectious Diseases, Walter Reed National Military Medical Center, Bethesda, Maryland, USA., Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland, USA., Leidos, Reston, Virginia, USA., Defense Threat Reduction Agency, Fort Belvoir, Virginia, USA.,
    1. Year: 2022
    2. Date: Mar
    3. Epub Date: 2022 02 14
  2. Journal: Open Forum Infectious Diseases
    1. 9
    2. 3
    3. Pages: ofac030
  4. Type of Article: Article
  5. Article Number: ofac030
  1. Abstract:

    The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort of health care workers (HCWs). A prospective cohort of HCWs, confirmed negative for SARS-CoV-2 exposure upon enrollment, were evaluated for SARS-CoV-2 infection by monthly analysis of SARS-CoV-2 antibodies as well as referral for polymerase chain reaction testing whenever they exhibited symptoms of coronavirus disease 2019 (COVID-19). Participants completed the standardized and validated FLU-PRO Plus symptom questionnaire scoring viral respiratory disease symptom intensity and frequency at least twice monthly during baseline periods of health and each day they had any symptoms that were different from their baseline. Two hundred sixty-three participants were enrolled between August 25 and December 31, 2020. Through February 28, 2021, 12 participants were diagnosed with SARS-CoV-2 infection. Symptom analysis demonstrated that all 12 had at least mild symptoms of COVID-19, compared with baseline health, near or at time of infection. These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/ofid/ofac030
  3. PMID: 35198647
  4. PMCID: PMC8860153
  5. PII : ofac030

Library Notes

  1. Fiscal Year: FY2021-2022
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