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T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals

  1. Author:
    Naranbhai, Vivek
    Nathan, Anusha
    Kaseke, Clarety
    Berrios, Cristhian
    Khatri, Ashok
    Choi, Shawn
    Getz, Matthew A
    Tano-Menka, Rhoda
    Ofoman, Onosereme
    Gayton, Alton
    Senjobe, Fernando
    Zhao, Zezhou
    St Denis, Kerri J
    Lam, Evan C
    Carrington,Mary
    Garcia-Beltran, Wilfredo F
    Balazs, Alejandro B
    Walker, Bruce D
    Iafrate, A John
    Gaiha, Gaurav D

  2. Author Address

    Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa. Electronic address: vnaranbhai@mgh.harvard.edu., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Program in Health Sciences & Technology, Harvard Medical School, Massachusetts Institute of Technology, Boston, MA 02115, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Massachusetts General Hospital Endocrine Division and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD 20892, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; The Broad Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Institute for Medical Engineering and Science, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: ggaiha@mgh.harvard.edu.,
    1. Year: 2022
    2. Date: Feb 03
    3. Epub Date: 2022 02 03
  2. Journal: Cell
    1. 185
  4. Type of Article: Article
  1. Abstract:

    The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from antibody responses, although the extent to which these substitutions in spike and non-spike proteins affect T cell recognition is unknown. In this study, we show that T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins. However, we also identify a subset of individuals (~21%) with a >50% reduction in T cell reactivity to the Omicron spike. Evaluation of functional CD4+ and CD8+ memory T cell responses confirmed these findings and revealed that reduced recognition to Omicron spike is primarily observed within the CD8+ T cell compartment potentially due to escape from HLA binding. Booster vaccination enhanced T cell responses to Omicron spike. In contrast to neutralizing immunity, these findings suggest preservation of T cell responses to the Omicron variant, although with reduced reactivity in some individuals. Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.cell.2022.01.029
  3. PMID: 35202566
  4. PMCID: PMC8810349
  5. PII : S0092-8674(22)00140-4

Library Notes

  1. Fiscal Year: FY2021-2022
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