Skip NavigationSkip to Content
Return Return to Search Results

Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV

  1. Author:
    Hung, Rachel K Y
    Binns-Roemer,Elizabeth
    Booth, John W
    Hilton, Rachel
    Harber, Mark
    Santana-Suarez, Beatriz
    Campbell, Lucy
    Fox, Julie
    Ustianowski, Andrew
    Cosgrove, Catherine
    Burns, James E
    Clarke, Amanda
    Price, David A
    Chadwick, David
    Onyango, Denis
    Hamzah, Lisa
    Bramham, Kate
    Sabin, Caroline A
    Winkler,Cheryl
    Post, Frank A

  2. Author Address

    King 39;s College London, London, UK., Basic Research Laboratory, Frederick National Laboratory for Cancer Research and the National Cancer Institute, Frederick, Maryland, USA., Barts Health NHS Trust, London, UK., Guy 39;s and St Thomas 39; NHS Foundation Trust, London, UK., Royal Free London Hospital NHS Foundation Trust, London, UK., Pennine Acute Hospitals NHS Foundation Trust, Manchester, UK., St George 39;s Hospital NHS Foundation Trust, London, UK., University College London, London, UK., Central and North West London NHS Foundation Trust, London, UK., Brighton and Sussex University Hospital NHS Trust, Brighton, UK., Brighton and Sussex Medical School Department of Infectious Disease, Brighton, UK., The Newcastle Upon Tyne Hospitals, Newcastle, UK., South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK., Africa Advocacy Foundation, London, UK., King 39;s College Hospital NHS Foundation Trust, London, UK.,
    1. Year: 2022
    2. Date: Apr 25
    3. Epub Date: 2022 01 25
  2. Journal: Kidney International Reports
    1. 7
    2. 4
    3. Pages: 786-796
  4. Type of Article: Article
  1. Abstract:

    Variants of the APOL1 gene are associated with chronic kidney disease (CKD) in people of African ancestry, although evidence for their impact in people with HIV are sparse. We conducted a cross-sectional study investigating the association between APOL1 renal risk alleles and kidney disease in people of African ancestry with HIV in the UK. The primary outcome was end-stage kidney disease (ESKD; estimated glomerular filtration rate [eGFR] of < 15 ml/min per 1.73 m2, chronic dialysis, or having received a kidney transplant). The secondary outcomes included renal impairment (eGFR < 60 ml/min per 1.73 m2), albuminuria (albumin-to-creatinine ratio [ACR] >30 mg/mmol), and biopsy-proven HIV-associated nephropathy (HIVAN). Multivariable logistic regression was used to estimate the associations between APOL1 high-risk genotypes (G1/G1, G1/G2, G2/G2) and kidney disease outcomes. A total of 2864 participants (mean age 48.1 [SD 10.3], 57.3% female) were genotyped, of whom, 354 (12.4%) had APOL1 high-risk genotypes, and 99 (3.5%) had ESKD. After adjusting for demographic, HIV, and renal risk factors, individuals with APOL1 high-risk genotypes were at increased odds of ESKD (odds ratio [OR] 10.58, 95% CI 6.22-17.99), renal impairment (OR 5.50, 95% CI 3.81-7.95), albuminuria (OR 3.34, 95% CI 2.00-5.56), and HIVAN (OR 30.16, 95% CI 12.48-72.88). An estimated 49% of ESKD was attributable to APOL1 high-risk genotypes. APOL1 high-risk genotypes were strongly associated with kidney disease in people of African ancestry with HIV and accounted for approximately half of ESKD cases in this cohort. © 2022 International Society of Nephrology. Published by Elsevier Inc.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.ekir.2022.01.1054
  3. PMID: 35497797
  4. PMCID: PMC9039486
  5. PII : S2468-0249(22)01072-5

Library Notes

  1. Fiscal Year: FY2021-2022
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel