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Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients

  1. Author:
    Dai, Lu
    Lu, Yong-Chen
    Chen, Jungang
    Plaisance-Bonstaff, Karlie
    Mu, Shengyu
    Forrest, J Craig
    Whitby,Denise
    Post, Steven R
    Qin, Zhiqiang

  2. Author Address

    Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Department of Medicine, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans, LA, United States., Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Department of Microbiology and Immunology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.,
    1. Year: 2022
    2. Date: Apr 19
    3. Epub Date: 2022 04 19
  2. Journal: Frontiers in Microbiology
    1. 13
    2. Pages: 882520
  4. Type of Article: Article
  5. Article Number: 882520
  1. Abstract:

    Kaposi's Sarcoma (KS) caused by Kaposi's sarcoma-associated herpesvirus (KSHV) continues to be the most common AIDS-associated tumor. Involvement of the oral cavity represents one of the most common clinical manifestations of this tumor. Numerous types of cancer are associated with the alterations of in components of the microbiome. However, little is known about how KSHV coinfection affects the oral microbiome in HIV+ patients, especially in a "pre-cancer" niche. Using 16S rRNA pyrosequencing, we found that oral shedding of KSHV correlated with altered oral microbiome signatures in HIV+ patients, including a reduction in the microbiota diversity, changing the relative composition of specific phyla and species, and regulating microbial functions. Furthermore, we found that Streptococcus sp., one of the most increased species in the oral cavity of HIV+/KSHV+ patients, induced KSHV lytic reactivation in primary oral cells. Together, these data indicate that oral shedding of KSHV may manipulate the oral microbiome to promote viral pathogenesis and tumorigenesis especially in immunocompromised patients. Copyright © 2022 Dai, Lu, Chen, Plaisance-Bonstaff, Mu, Forrest, Whitby, Post and Qin.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fmicb.2022.882520
  3. PMID: 35516440
  4. PMCID: PMC9063630

Library Notes

  1. Fiscal Year: FY2021-2022
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