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A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM)

  1. Author:
    Kennedy, J.
    Vicari, A. P.
    Saylor, V.
    Zurawski, S. M.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Zlotnik, A.

  2. Author Address

    Zlotnik A DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol 901 Calif Ave Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunol Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol Palo Alto, CA 94304 USA NCI, Mammalian Genet Lab, ABL Basic Res Program, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA
    1. Year: 2000
  2. Journal: Journal of Leukocyte Biology
    1. 67
    2. 5
    3. Pages: 725-734
  4. Type of Article: Article
  1. Abstract:

    cDNA library subtraction techniques were used to identify transcripts expressed by activated mouse alpha beta TCR+ CD4(-)CD8(-) (double-negative; DN) T cells, a subset of natural killer T (NKT) cells. The most frequent cDNAs identified included the chemokines TCA3, macrophage inflammatory protein-1 alpha (MIP-1 alpha), MIP-1 beta, and lymphotactin (LPTN), the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma), and a granzyme, We also identified a new member of the immunoglobulin superfamily (Ig-SF), This molecule was designated class I-restricted T cell-associated molecule (CRTAM) as a result of its restricted expression pattern in T cells. Human CRTAM was also identified, and shares the same expression pattern as the mouse molecule. LPTN and CRTAM exhibit the same expression pattern in T cells, suggesting the existence of a gene expression program common to class I-MHC-restricted T cells. [References: 53]

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