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Inhibition of MDA-MB-231 human breast tumor xenografts and HER2 expression by anti-tumor agents GAP31 and MAP30

  1. Author:
    Lee-Huang, S.
    Huang, P. L.
    Sun, Y. T.
    Chen, H. C.
    Kung, H. F.
    Murphy, W. J.

  2. Author Address

    Murphy WJ NCI, Frederick Canc Res & Dev Ctr, SAIC Bldg 567,Room 210 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, MD 21702 USA NYU, Sch Med, Dept Biochem New York, NY 10016 USA NICHHD, Endocrinol & Reprod Res Branch, NIH Bethesda, MD 20892 USA NCI, Frederick Canc Res & Dev Ctr, Lab Biochem Physiol Frederick, MD 21701 USA Massachusetts Gen Hosp, Dept Med Boston, MA 02114 USA Harvard Univ, Sch Med Boston, MA 02114 USA
    1. Year: 2000
  2. Journal: Anticancer Research
    1. 20
    2. 2A
    3. Pages: 653-659
  4. Type of Article: Article
  1. Abstract:

    GAP31 (Gelonium protein of 31 kDa) and MAP30 (Momordica protein of 30 kDa) are agents isolated from the medicinal plants Gelonium multiflorum and Momordica charantia, respectively. The current study was conducted to investigate the efficacy of GAP31 and MAP30 on estrogen-independent and highly metastatic human breast tumor MDA-MB-231 both in vitro and in vivo. The effect of these agents on the expression of breast tumor antigen HER2 (also known as neu or as c-erbB 2) was also examined. Treatment of MDA-MB-231 breast cancer cells with GAP31 and MAP30 resulted in inhibition of cancer cell proliferation as well as inhibition of the expression of HER2 gene in vitro. When MDA-MB-231 human breast cancer cells were transferred into SCID mice, the mice developed extensive metastases and all mice succumbed to tumor by day 46. Treatment of the human breast cancer bearing SCID mice with GAP32 or MAP30 at 10 mu g/injection EOD for 10 injections resulted in significant increases in survival, with 20-25% of the mice remaining tumor free for 96 days. Thus antitumor agents GAP31 and MAP30 are effective against human br east cancer MDA-MB-231 in vitro and in vivo. There agents may therefore be of potential therapeutic use against breast carcinomas. [References: 30]

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