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Development of a multiassay algorithm (MAA) to identify recent HIV infection in newly diagnosed individuals in Indonesia

  1. Author:
    Wulan, Wahyu Nawang
    Yunihastuti, Evy
    Arlinda, Dona
    Merati, Tuti Parwati
    Wisaksana, Rudi
    Lokida, Dewi
    Grossman, Zehava
    Huik, Kristi
    Lau,Chuen-Yen
    Susanto, Nugroho Harry
    Kosasih, Herman
    Aman, Abu Tholib
    Ang, Sunarto
    Evalina, Rita
    Ayu Yuli Gayatri, Anak Agung
    Hayuningsih, Chakrawati
    Indrati, Agnes Rengga
    Kumalawati, July
    Mutiawati, Vivi Keumala
    Realino Nara, Mario Bernardinus
    Nurulita, Asvin
    Rahmawati, Rahmawati
    Rusli, Adria
    Rusli, Musofa
    Sari, Dewi Yennita
    Sembiring, Justina
    Udji Sofro, Muchlis Achsan
    Susanti, Wiwi Endang
    Tandraeliene, Janice
    Tanzil, Fransisca Lianiwati
    Neal, Aaron
    Karyana, Muhammad
    Sudarmono, Pratiwi
    Maldarelli, Frank

  2. Author Address

    Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia., The Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta 10560, Indonesia., HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., Health Policy Agency, Ministry of Health Republic of Indonesia, Jakarta 10560, Indonesia., Sanglah Hospital, Denpasar 80113, Indonesia., dr. Hasan Sadikin Hospital, Bandung 40161, Indonesia., Tangerang District Hospital, Tangerang 15111, Indonesia., School of Public Health, Tel Aviv University, Tel Aviv 69978, Israel., Department of Microbiology, University of Tartu, 50090 Tartu, Estonia., dr. Sardjito Hospital, Yogyakarta 55284, Indonesia., A. Wahab Sjahranie Hospital, Samarinda 75123, Indonesia., H Adam Malik Hospital, Medan 20136, Indonesia., dr. Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., dr. Zainoel Abidin Hospital, Banda Aceh 24415, Indonesia., dr. TC Hillers Hospital, Maumere 86111, Indonesia., dr. Wahidin Sudirohusodo Hospital, Makassar 90245, Indonesia., dr. H. M. Ansari Saleh Hospital, Banjarmasin 70234, Indonesia., Prof. Dr. Sulianti Saroso Infectious Hospital, Jakarta 14340, Indonesia., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo Hospital, Surabaya 60286, Indonesia., Persahabatan Hospital, Jakarta 132030, Indonesia., Abepura Hospital, Jayapura 99351, Indonesia., dr. Kariadi Hospital, Semarang 50244, Indonesia., dr. Soedarso Hospital, Pontianak 78124, Indonesia., St. Carolus Hospital, Jakarta 10440, Indonesia., Budi Kemuliaan Hospital, Batam 29483, Indonesia., Collaborative Clinical Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Department of Microbiology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia.,
    1. Year: 2023
    2. Date: Oct 20
    3. Epub Date: 2023 09 21
  2. Journal: iScience
    1. 26
    2. 10
    3. Pages: 107986
  4. Type of Article: Article
  5. Article Number: 107986
  1. Abstract:

    Ongoing HIV transmission is a public health priority in Indonesia. We developed a new multiassay algorithm (MAA) to identify recent HIV infection. The MAA is a sequential decision tree based on multiple biomarkers, starting with CD4+ T cells >200/µL, followed by plasma viral load (pVL) > 1,000 copies/ml, avidity index (AI) < 0 · 7, and pol ambiguity < 0 · 47%. Plasma from 140 HIV-infected adults from 19 hospitals across Indonesia (January 2018 - June 2020) was studied, consisting of a training set (N = 60) of longstanding infection (>12-month) and a test set (N = 80) of newly diagnosed (=1-month) antiretroviral (ARV) drug naive individuals. Ten of eighty (12 · 5%) newly diagnosed individuals were classified as recent infections. Drug resistance mutations (DRMs) against reverse transcriptase inhibitors were identified in two individuals: one infected with HIV subtype C (K219Q, V179T) and the other with CRF01_AE (V179D). Ongoing HIV transmission, including infections with DRMs, is substantial in Indonesia. © 2023.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.isci.2023.107986
  3. PMID: 37854696
  4. PMCID: PMC10579430
  5. PII : S2589-0042(23)02063-1

Library Notes

  1. Fiscal Year: FY2023-2024
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