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Prolonged mpox disease in people with advanced HIV: characterization of mpox skin lesions

  1. Author:
    O'Shea, Jesse [ORCID]
    Zucker, Jason [ORCID]
    Stampfer, Samuel
    Cash-Goldwasser, Shama
    Minhaj, Faisal S
    Dretler, Alexandra
    Cheeley, Justin
    Chaudhuri, Shaoli
    Gallitano, Stephanie M
    Gunaratne, Shauna
    Parkinson, Melissa
    Epling, Brian [ORCID]
    Morcock,David
    Sereti, Irini
    Deleage,Claire

  2. Author Address

    Mpox Emergency Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA., Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY, USA., Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA., Infectious Disease Specialists of Atlanta and Emory Decatur Hospital, Decatur, GA, USA., Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA., HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health., AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research.,
    1. Year: 2023
    2. Date: Mar 26
    3. Epub Date: 2023 11 29
  2. Journal: The Journal of Infectious Diseases
    1. 229
    2. Suppl. 2
    3. Pages: S243-S248
  4. Type of Article: Article
  5. Article Number: jiad532
  1. Abstract:

    We report three complicated and prolonged cases of mpox in people with advanced HIV not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T-cells, with a strong type-I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2023.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiad532
  3. PMID: 38019806
  4. PMCID: PMC10965209
  5. View record in Web of Science®
  6. WOS: 001203463900006
  7. PII : 7455193

Library Notes

  1. Fiscal Year: FY2023-2024
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