Skip NavigationSkip to Content
Return Return to Search Results

T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas

  1. Author:
    Sayers, T. J.
    Brooks, A. D.
    Seki, N.
    Smyth, M. J.
    Yagita, H.
    Blazar, B. R.
    Malyguine, A. M.

  2. Author Address

    Sayers TJ NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Ckin Serv Program Bldg 560,Room 31-30 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Ckin Serv Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Intramural Res Support Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Expt Immunol, DBS Frederick, MD 21702 USA Austin Res Inst, Cellular Cytotox Lab Heidelberg Vic Australia Juntendo Univ, Sch Med, Dept Immunol Tokyo 113 Japan Univ Minnesota, Dept Pediat, Div Bone Marrow Transplantat Minneapolis, MN 55455 USA
    1. Year: 2000
  2. Journal: Journal of Leukocyte Biology
    1. 68
    2. 1
    3. Pages: 81-86
  4. Type of Article: Article
  1. Abstract:

    Activated T cells lyse the murine renal cancer Renca. We have examined the mechanism of tumor cell lysis with the use of T tells derived from C57BL/6, BALB/c, B6.gld, and B6.Pfp(-/-) mice, C57BL/6 and BALB/c T cells can lyse Renca cells through the use of both granule- and Fas Ligand (FasL)-mediated pathways. However, B6.gld T cells predominantly use granule-mediated killing, whereas B6.Pfp(-/-) T cells use Fast. The lysis of Renca by Pfp(-/-) T cells is only partially inhibited by the caspase inhibitor ZVAD-FMK, suggesting that caspase-independent signaling is also important for Renca cell lysis, When the reactive oxygen scavenger butylated hydroxyanisole was used alone or hi combination with ZVAD-FMK a substantial reduction of Renca lysis was observed. Therefore, the caspase-independent generation of reactive oxygen intermediates in Renca after Fas triggering contributes to the lysis of these cells. [References: 28]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel