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The von Hippel-Lindau tumor suppressor targets to mitochondrial

  1. Author:
    Shiao, Y. H.
    Resau, J. H.
    Nagashima, K.
    Anderson, L. M.
    Ramakrishna, G.

  2. Author Address

    Shiao YH NCI, Comparat Carcinogenesis Lab, Frederick Canc Res & Dev Ctr, NIH Bldg 538,Room 205 Frederick, MD 21702 USA NCI, Comparat Carcinogenesis Lab, Frederick Canc Res & Dev Ctr, NIH Frederick, MD 21702 USA NCI, ABL Basic Res Program, Frederick Canc Res & Dev Ctr, NIH Frederick, MD 21702 USA NCI, Lab Cell & Mol Struct, Sci Applicat Int Corp Frederick, Frederick Canc Res & Dev Ctr,NIH Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Cancer Research
    1. 60
    2. 11
    3. Pages: 2816-2819
  4. Type of Article: Article
  1. Abstract:

    Subcellular localization of von Hippel-Lindau (VHL) tumor suppressor may clarify its role in tumorigenesis. In rat kidney, we observed a granular cytoplasmic immunostaining of VHL, as seen in human tissues. The green fluorescent protein (GFP)-tagged VHL also appeared as cytoplasmic granules in vitro and was colocalized with a mitochondrion-selective dye. Immunogold electron microscopy localized VHL specifically to the mitochondrion. Mitochondria retaining GFP-VHL fusion protein, mimicking an insertional VHL mutant, displayed abnormal phenotypes. Among these, small mitochondria have been observed in clear cell renal carcinomas known to have frequent VHL alterations. Thus, VHL may contribute to tumorigenesis through mitochondria-based action. [References: 20]

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