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Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)

  1. Author:
    Wang, W.
    Soto, H.
    Oldham, E. R.
    Buchanan, M. E.
    Homey, B.
    Catron, D.
    Jenkins, N.
    Copeland, N. G.
    Gilbert, D. J.
    Nguyen, N.
    Abrams, J.
    Kershenovich, D.
    Smith, K.
    McClanahan, T.
    Vicari, A. P.
    Zlotnik, A.

  2. Author Address

    Zlotnik A DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol Palo Alto, CA 94304 USA Schering Plough Lab Immunol Res F-69572 Dardilly France NCI, Frederick Canc Res & Dev Ctr, Mammalian Genet Lab Frederick, MD 21702 USA Inst Nacl Nutr Salvador Zubiran, Dept Gastroenterol Mexico City 14000 DF Mexico
    1. Year: 2000
  2. Journal: Journal of Biological Chemistry
    1. 275
    2. 29
    3. Pages: 22313-22323
  4. Type of Article: Article
  1. Abstract:

    We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2. Human and mouse CCL28 share 83% identity at the amino acid and 76% at the nucleic acid levels. We also identified the mouse homologues of CCL28 and of CCR10, which map to mouse chromosomes 13 and 11, respectively, CCL28 is expressed in a variety of human and mouse tissues, and it appears to be predominantly produced by epithelial cells. Both human and mouse CCL28 induce calcium mobilization in human and mouse CCL28 expressing transfectants. CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor. In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells. [References: 25]

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