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Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction

  1. Author:
    Xu, R. H.
    Peng, Y.
    Fan, J.
    Yan, D. H.
    Yamagoe, S.
    Princler, G.
    Sredni, D.
    Ozato, K.
    Kung, H. F.

  2. Author Address

    Xu RH Univ Wisconsin, Wisconsin Alumni Res Fdn, WiCell Res Inst 614 Walnut St Madison, WI 53705 USA Univ Wisconsin, Wisconsin Alumni Res Fdn, WiCell Res Inst Madison, WI 53705 USA NCI, Basic Res Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr,NIH Frederick, MD 21701 USA NICHHD, Lab Cellular & Mol Biophys, NIH Bethesda, MD 20892 USA Bar Ilan Univ, Canc Aids & Immunol Res Inst, Interdisciplinary Dept Ramat Gan Israel NICHHD, Lab Mol Growth Regulat, NIH Bethesda, MD 20892 USA Univ Hong Kong, Inst Mol Biol Pokfulam Hong Kong Peoples R China
    1. Year: 2000
  2. Journal: Developmental Dynamics
    1. 218
    2. 4
    3. Pages: 628-635
  4. Type of Article: Article
  1. Abstract:

    We have previously demonstrated that the transcription factor, AP-1 (c-jun/c-fos heterodimer), mediates fibroblast growth factor (FGF) signaling during mesoderm induction in Xenopus embryo. In the present studies, we show that histone acetylation is involved in FGF-mediated signaling leading to mesoderm induction, Histone acetylation is a dynamic process regulated by the activities of two histone-modifying enzymes, the histone acetyltransferase(s) and histone deacetylase(s) (HDACs), We found that basal and FGF-regulated activator protein 1 (AP-1) activity in Xenopus embryo is markedly reduced by treatment of trichostatin A (TSA), a specific inhibitor of HDAC. However, activity of another transcription factor, NF kappa B, is enhanced by TSA treatment. AP-1-mediated mesoderm induction in the animal caps is dramatically suppressed by TSA at a dose-dependent manner. This suppression can be rescued by ectopic expression of HDAC3 at early stage, Finally, are found that histone acetylation in animal caps is inhibited by FGF whereas enhanced by TSA las It control). Therefore, we propose that histone acetylation is a checkpoint for transduction of the FGF/AP-1 signals to induce mesoderm, Published 2000 Wiley-Liss, Inc.dagger. [References: 44]

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