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The oral microbiome and all-cause mortality in aUS population representative prospective cohort

  1. Author:
    Vogtmann, Emily [ORCID]
    Yano, Yukiko [ORCID]
    Shi, Jianxin
    Wan,Yunhu [ORCID]
    Purandare, Vaishnavi [ORCID]
    McLean, Jody [ORCID]
    Li, Shilan
    Knight, Rob [ORCID]
    Kahle, Lisa
    Hullings, Autumn G
    Hua,Xing
    Graubard, Barry I [ORCID]
    Gillison, Maura L
    Caporaso, J Gregory
    Bokulich, Nicholas A [ORCID]
    Blaser, Martin J
    Freedman, Neal D [ORCID]
    Chaturvedi, Anil K
    Abnet, Christian C [ORCID]

  2. Author Address

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Frederick National Laboratory for Cancer Research/Leidos Biomedical Research Laboratory, Inc, Frederick, MD, USA., National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD, USA., Johns Hopkins University, Baltimore, MD, USA., Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA., Information Management Services, Inc, Calverton, MD, USA., Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA., Department of Thoracic and Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Center for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA., Laboratory of Food Systems Biotechnology, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Center for Advanced Biotechnology and Medicine, Rutgers, Piscataway, NJ, USA., Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.,
    1. Year: 2025
    2. Date: Jun 13
    3. Epub Date: 2025 06 13
  2. Journal: The Journal of Infectious Diseases
  4. Type of Article: Article
  5. Article Number: jiaf321
  1. Abstract:

    No large studies have evaluated whether the human oral microbiome is directly associated with mortality. We evaluated prospective associations between the oral microbiome, measured using 16S rRNA gene sequencing, from participants aged 20-69 years in the 2009-2012 cycles of the National Health and Nutrition Examination Survey (NHANES) and all-cause mortality (N=7,721, representing ~194 million individuals). Alpha diversity was inversely associated with mortality, and some significant associations were observed with the beta diversity matrices. Higher relative abundances of Granulicatella and Lactobacillus were associated with increased risk, while Bacteroides was associated with decreased all-cause mortality at the genus level. Results suggest oral bacterial communities may be important contributors to health and disease. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2025.

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External Sources

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  2. DOI: 10.1093/infdis/jiaf321
  3. PMID: 40513117
  4. PII : 8162318

Library Notes

  1. Fiscal Year: FY2024-2025
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