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The Tax Gene Sequences Form Two Divergent Monophyletic Lineages Corresponding to Types I and Ii of Simian and Human T-Cell Leukemia Lymphotropic Viruses

  1. Author:
    Giri, A.
    Slattery, J. P.
    Heneine, W.
    Gessain, A.
    Rivadeneira, E.
    Desrosiers, R. C.
    Rosen, L.
    Anthony, R.
    Pamungkas, J.
    Iskandriati, D.
    Richards, A. L.
    Herve, V.
    McClure, H.
    Obrien, S. J.
    Franchini, G.

  2. Author Address

    Franchini G NCI BASIC RES LAB NIH BLDG 37 ROOM 6A11 BETHESDA, MD 20892 USA NCI BASIC RES LAB NIH BETHESDA, MD 20892 USA NCI LAB GENOM DIVERS FREDERICK CANC RES & DEV CTR FREDERICK, MD 21702 USA CTR DIS CONTROL & PREVENT RETROVIRUS DIS BRANCH DIV VIRAL & RICKETTSIAL DIS CTR INFECT DIS ATLANTA, GA 30333 USA INST PASTEUR UNITE EPIDEMIOL VIRUS ONCOGENES F-75724 PARIS 15 FRANCE INST PASTEUR SERV INFORMAT SCI F-75724 PARIS 15 FRANCE HARVARD UNIV SCH MED DIV MICROBIOL SOUTHBOROUGH, MA 01772 USA UNIV HAWAII PACIFIC BIOMED RES CTR HONOLULU, HI 96816 USA AMER UNIV CARIBBEAN BELIZE CITY BELIZE BOGOR AGR UNIC PRIMATE RES CTR BOGOR INDONESIA INST PASTEUR BANGUI CENTRAL AFRICAN REPUBLIC YERKES REG PRIMATE RES CTR ATLANTA, GA 30322 USA USN MED RES UNIT N2 APO, AP 96520 USA
    1. Year: 1997
  2. Journal: Virology
    1. 231
    2. 1
    3. Pages: 96-104
  4. Type of Article: Article
  1. Abstract:

    Evolutionary associations of human and simian T-cell leukemia/lymphotropic viruses I and II (HTLV-I/II and STLV-I/II) are inferred from phylogenetic analysis of lax gene sequences. Samples studied consisted of a geographically diverse assemblage of viral strains obtained from 10 human subjects and 20 individuals representing 12 species of nonhuman primates. Sequence analyses identified distinct substitutions, which distinguished between viral types I and II, irrespective of host species. Phylogenetic reconstruction of nucleotide sequences strongly supported two major evolutionary groups corresponding to viral types I and II. With the type I lineage, clusters were composed of strains from multiple host species. A genetically diverse, monophyletic lineage consisting of eight new viral strains from several species of Asian macaques was identified. The second lineage consisted of a monophyletic assemblage of HTLV-II/STLV-II strains from Africa and the New World, including an isolate from a pygmy chimp (Pan paniscus) as an early divergence within the lineage. High levels of genetic variation among strains from Asian STLV-I macaque suggest the virus arose in Asia. Evidence of the origin of the type II virus is less clear, but diversity among HTLV-II variants from a single isolated population of Mbati villagers is suggestive but not proof of an African origin. (C) 1997 Academic Press. [References: 58]

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