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P-glycoprotein-overexpressing multidrug-resistant cells are resistant to infection by enveloped viruses that enter via the plasma membrane

  1. Author:
    Raviv, Y.
    Puri, A.
    Blumenthal, R.

  2. Author Address

    Raviv Y NCI, Intramural Res Support Program, SAIC Frederick,Lab Expt & Computat Biol, Frederick Canc Res & Dev Ctr Bldg 469,Room 211 Frederick, MD 21702 USA NCI, Intramural Res Support Program, SAIC Frederick,Lab Expt & Computat Biol, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Faseb Journal
    1. 14
    2. 3
    3. Pages: 511-515
  4. Type of Article: Article
  1. Abstract:

    The multidrug resistance gene product P-glycoprotein confers drug resistance to tumor cells by acting as a transporter that blocks: the entry into the cell of a great variety of drugs and hydrophobic pep tides. In this study we find that in drug-resistant cells, the insertion of the influenza virus fusion protein (hemagglutinin-2) into the plasma membrane is blocked and that the fusion of the viral envelope with the plasma membrane of these cells is impaired. Multidrug-resistant cells display significant resistance to infection by envelope viruses that invade cells by fusion with the plasma membrane, but not to infection by pH-dependent viruses that penetrate cells by fusion with endocytic vesicles, These observations suggest that multidrug resistance phenomena may protect cells from infection by a large group of disease-causing viruses that includes human immunodeficiency virus, herpes simplex virus, and some cancer-inducing retroviruses. [References: 24]

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