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Ets1 oncogene induction by ELF-modulated 50 MHz radiofrequency electromagnetic field

  1. Author:
    Romano-Spica, V.
    Mucci, N.
    Ursini, C. L.
    Ianni, A.
    Bhat, N. K.

  2. Author Address

    Romano-Spica V Catholic Univ Sacred Heart, Inst Hyg & Publ Hlth, Fac Med LF Vito 1 I-00168 Rome Italy Catholic Univ Sacred Heart, Inst Hyg & Publ Hlth, Fac Med I-00168 Rome Italy ISPESL, Higher Inst Occupat Safety & Hlth, Dept Occupat Med Monteporzio Catone Italy Sci Applicat Int Corp Inc, Recombinant DNA Lab, Frederick Canc Res & Dev Ctr Frederick, MD USA
    1. Year: 2000
  2. Journal: Bioelectromagnetics
    1. 21
    2. 1
    3. Pages: 8-18
  4. Type of Article: Article
  1. Abstract:

    We have analyzed gene expression in hemopoietic and testicular cell types after their exposure to 50 MHz radiofrequency (RF) non-ionizing radiation modulated (80%) with a 16 Hz frequency. The exposure system generates a 0.2 mu T magnetic field parallel to the ground and a 60 V/m electric field orthogonal to the earth's magnetic field. Exposure conditions: were selected so as to interfere with the calcium ion flow. Under these electromagnetic field (EMF) conditions, we observed an overexpression of the ets1 mRNA in Jurkat T-lymphoblastoid and Leydig TM3 cell lines. This effect was observed only in the presence of the 16 Hz modulation, corresponding to the resonance frequency for calcium ion with a DC magnetic field of 45.7 mu T. We have also identified a putative candidate gene repressed after EMF exposure. The experimental model described in this paper may contribute to the understanding of the biological mechanisms involved in EMF effects. (C) 2000 Wiley-Liss, Inc. [References: 83]

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