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Slow Dendritic Transport of Dissociated Mouse Hippocampal Neurons Exposed to Aluminum

  1. Author:
    Wakayama, I.
    Song, K. J.
    Nerurkar, V. R.
    Yoshida, S.
    Garruto, R. M.

  2. Author Address

    Garruto RM NINCDS FREDERICK CANC RES & DEV CTR BLDG 376 POB B FREDERICK, MD 21702 USA KANSAI COLL ORIENTAL MED RES CTR NEUROL DIS KUMATORI OSAKA 59004 JAPAN NINCDS NIH CENT NERVOUS SYST STUDIES LAB BETHESDA, MD 20892 USA KOREA UNIV COLL MED DEPT MICROBIOL SEOUL 136705 SOUTH KOREA LEAHI HOSP PACIFIC BIOMED RES CTR RETROVIRUS RES LAB HONOLULU, HI 96816 USA WAKAYAMA MED COLL DIV NEUROL DIS WAKAYAMA 640 JAPAN
    1. Year: 1997
  2. Journal: Brain Research
    1. 748
    2. 1-2
    3. Pages: 237-240
  4. Type of Article: Article
  1. Abstract:

    We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration. [References: 30]

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