Skip NavigationSkip to Content
Return Return to Search Results

HIV-inhibitory natural products part 61 - Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea

  1. Author:
    Rashid, M. A.
    Gustafson, K. R.
    Cardellina, J. H.
    Boyd, M. R.

  2. Author Address

    NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program, Div Canc Treatment & Diag, FCRDC, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Natural Product Letters
    1. 15
    2. 1
    3. Pages: 21-26
  4. Type of Article: Article
  1. Abstract:

    Anti-HIV bioassay-guided fractionation of an organic extract of Ochanostachys amentacea provided an HIV-inhibitory polyacetylenic acid. The identity of this compound was established as (-)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (1), also known as minquartynoic acid, by comparison of its physical and spectral data with previously reported values. Analysis of Mosher's ester derivatives of the methyl ester of 1 allowed assignment of S absolute stereochemistry to the lone chiral center. In an in vitro XTT-based anti-HIV assay, 2-5 mug/mL of minquartynoic acid (1) effectively inhibited human lymphoblastoid cell killing by HIV-1.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel