Skip NavigationSkip to Content
Return Return to Search Results

Evidence for increased T cell turnover and decreased thymic output in HIV infection

  1. Author:
    Douek, D. C.
    Betts, M. R.
    Hill, B. J.
    Little, S. J.
    Lempicki, R.
    Metcalf, J. A.
    Casazza, J.
    Yoder, C.
    Adelsberger, J. W.
    Stevens, R. A.
    Baseler, M. W.
    Keiser, P.
    Richman, D. D.
    Davey, R. T.
    Koup, R. A.

  2. Author Address

    NIAID, Vaccine Res Ctr, NIH, Room 3509, 40 Convent Dr, Bethesda, MD 20892 USA. NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. NIAID, Immunoregulat Lab, Clin & Mol Retrovirol Sect, Bethesda, MD 20892 USA. Vet Affairs Med Ctr, La Jolla, CA 92093 USA. Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA. Sci Applicat Int Corp, Clin Serv Program, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA. Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. NIH, Dept Crit Care Med, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA. NCI, Dept Expt Transplant & Immunol, Med Branch, Bethesda, MD 20892 USA. Douek DC NIAID, Vaccine Res Ctr, NIH, Room 3509, 40 Convent Dr, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Journal of Immunology
    1. 167
    2. 11
    3. Pages: 6663-6668
  4. Type of Article: Article
  1. Abstract:

    The effects of HIV infection upon the thymus and peripheral T cell turnover have been implicated in the pathogenesis of AIDS. In this study, we investigated whether decreased thymic output, increased T cell proliferation, or both can occur in HIV infection. We measured peripheral blood levels of TCR rearrangement excision circles (TREC) and parameters of cell proliferation, including Ki67 expression and ex vivo bromodeoxyuridine incorporation in 22 individuals with early untreated HIV disease and in 15 HIV-infected individuals undergoing temporary interruption of therapy. We found an inverse association between increased T cell proliferation with rapid viral recrudescence and a decrease in TREC levels. However, during early HIV infection, we found that CD45RO(- )CD27(high) (naive) CD4(+) T cell proliferation did not increase, despite a loss of TREC within naive CD4(+) T cells. A possible explanation for this is that decreased thymic output occurs in HIV-infected humans. This suggests that the loss of TREC during HIV infection can arise from a combination of increased T cell proliferation and decreased thymic output, and that both mechanisms can contribute to the perturbations in T cell homeostasis that underlie the pathogenesis of AIDS.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel