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Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica

  1. Author:
    Wang, S. S.
    Wheeler, C. M.
    Hildesheim, A.
    Schiffman, M.
    Herrero, R.
    Bratti, M. C.
    Sherman, M. E.
    Alfaro, M.
    Hutchinson, M. L.
    Morales, J.
    Lorincz, A.
    Burk, R. D.
    Carrington, M.
    Erlich, H. A.
    Apple, R. J.

  2. Author Address

    NCI, Interdisciplinary Studies Sect, Environm Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd, EPS MSC 7234, Bethesda, MD 20892 USA. NCI, Interdisciplinary Studies Sect, Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. Digene, Gaithersburg, MD USA. NCI, Lab Genet Divers, Div Basic Sci, Frederick, MD 21701 USA. Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA. Caja Costarricense Seguro Social, San Jose, Costa Rica. Women & Infants Hosp Rhode Isl, Dept Pathol, Providence, RI 02908 USA. Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA. Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10467 USA. Roche Mol Syst, Alameda, CA USA. Wang SS NCI, Interdisciplinary Studies Sect, Environm Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd, EPS MSC 7234, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Journal of Infectious Diseases
    1. 184
    2. 10
    3. Pages: 1310-1314
  4. Type of Article: Article
  1. Abstract:

    To examine human leukocyte antigen (HLA) involvement in the development of all grades of cervical neoplasia, a nested case- control study of 10,077 women in Guanacaste, Costa Rica, was conducted. Participants had invasive cervical cancer, high- grade squamous intraepithelial lesions (HSILs; n = 166), or low-grade squamous intraepithelial lesions (LSILs); were positive for human papillomavirus (HPV) with no evidence of cervical neoplasia (n = 320); or were HPV negative with no evidence of cervical neoplasia but with a history of high-risk sexual behavior (n = 173). Compared with women who were HPV negative, women with HLA-DRB1*1301 were associated with decreased risk for cancer/HSILs (odds ratio [OR], 0.4; 95% confidence interval [CI], 0.2-0.7) and for LSILs/HPV (OR, 0.6; 95% CI, 0.3-0.9). Women with both HLA-B*07 and HLA-DQB1*0302 had an 8.2-fold increased risk for cancer/HSILs (95% CI, 1.8- 37.2) and a 5.3-fold increased risk for LSILs/HPV (95% CI, 1.2- 23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection.

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