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Racial differences in HLA class II associations with hepatitis C virus outcomes

  1. Author:
    Thio, C. L.
    Thomas, D. L.
    Goedert, J. J.
    Vlahov, D.
    Nelson, K. E.
    Hilgartner, M. W.
    O'Brien, S. J.
    Karacki, P.
    Marti, D.
    Astemborski, J.
    Carrington, M.

  2. Author Address

    Johns Hopkins Univ, Dept Med, 424 N Bond St, Baltimore, MD 21231 USA. Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA. Johns Hopkins Med Inst, Dept Epidemiol, Baltimore, MD 21205 USA. Natl Canc Inst, Viral Epidemiol Branch, Rockville, MD USA. NCI, Lab Genom Divers, Frederick, MD 21701 USA. New York Acad Med, New York, NY USA. New York Presbyterian Hosp, Cornell Med Ctr, Dept Pediat, New York, NY USA. Thio CL Johns Hopkins Univ, Dept Med, 424 N Bond St, Baltimore, MD 21231 USA.
    1. Year: 2001
  2. Journal: Journal of Infectious Diseases
    1. 184
    2. 1
    3. Pages: 16-21
  4. Type of Article: Article
  1. Abstract:

    A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance and 374 matched persistently infected subjects. HLA-DQB1*0301 was weakly associated with viral clearance in combined ethnic groups (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.53-0.97) but was stronger in black subjects. In white subjects, viral clearance was associated with DRB1*0101 (OR, 0.32; 95% CI, 0.17-0.60) and its DQB1*0501 haplotype, whereas viral persistence was associated with DRB1*0301 (OR, 2.36; 95% CI, 1.23-4.52) and its DQB1*0201 haplotype. These results support a role for class II alleles in the immune response to HCV and underscore the importance of studying genetic associations in an ethnically diverse cohort.

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