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The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin

  1. Author:
    Lu, X. Y.
    Gruia-Gray, J.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Londos, C.
    Kimmel, A. R.

  2. Author Address

    NIDDKD, Cellular & Dev Biol Lab, NIH, Bldg 50, Room 3351 MSC 8028, Bethesda, MD 20892 USA. NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA. NCI, Mouse Canc Genet Program, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA. Kimmel AR NIDDKD, Cellular & Dev Biol Lab, NIH, Bldg 50, Room 3351 MSC 8028, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Mammalian Genome
    1. 12
    2. 9
    3. Pages: 741-749
  4. Type of Article: Article
  1. Abstract:

    The Perilipins are a family of intracellular neutral lipid droplet storage proteins that are responsive to acute protein kinase A-mediated, hormonal stimulation. Perilipin (Peri) expression appears to be limited to adipocytes and steroidogenic cells, in which intracellular neutral lipid hydrolysis is regulated by protein kinase A. We have isolated cDNA sets and overlapping genomic fragments of the murine Peri locus and mapped chromosomal location, transcription start sites, polyadenylylation sites, and intron/exon junctions. Data confirm that the Perilipins are encoded by a single-copy gene, with alternative and tissue-specific, mRNA splicing and polyadenylylation yielding four different protein species. The Perilipin proteins have identical similar to 22-kDa amino termini with distinct carboxyl terminal sequences of varying lengths. These genomic and transcriptional maps of murine. Perilipin are also essential for evaluating presumptive endogenous and targeted mutations within the locus. The N- terminal identity region of the Perilipins defines a sequence motif, which we term PAT, that is shared with the ADRP and TIP47 proteins; additionally, the PAT domain may represent a novel, conserved pattern for lipid storage droplet (LSD) proteins of vertebrates and invertebrates alike. Comparative genomics suggest the presence of related LSD genes in species as diverse as Drosophila and Dictyostelium.

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