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The murine Ly49 family: Form and function

  1. Author:
    Makrigiannis, A. P.
    Anderson, S. K.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Intramural Res Support Program, Bldg 560, Room 31-93, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Intramural Res Support Program, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Div Basic Sci, Lab Exp Immunol, Frederick, MD 21702 USA. Anderson SK NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Intramural Res Support Program, Bldg 560, Room 31-93, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Archivum Immunologiae et Therapiae Experimentalis
    1. 49
    2. 1
    3. Pages: 47-50
  4. Type of Article: Review
  1. Abstract:

    The activity of natural killer (NK) cells is regulated by surface receptors that recognize class I MHC. Murine NK cells express a large family of lectin-related receptors (Ly49s) to perform this function, while human NK cells utilize a separate group of proteins containing Ig-related domains (KIRs). Although these receptor families are not structurally related, the Ly49 family appears to be the functional equivalent of human KIRs, since it uses similar signal transduction pathways for either activation or inhibition of NK cell function. Therefore, lessons learned from the study of the murine MHC class I receptor system may be relevant to human NK function. This review summarizes the current state of knowledge of the Ly49 family.

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