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The P120-V-Abl Protein Interacts With E2f-1 and Regulates E2f-1 Transcriptional Activity

  1. Author:
    Birchenallroberts, M. C.
    Yoo, Y. D.
    Bertolette, D. C.
    Lee, K. H.
    Turley, J. M.
    Bang, O. S.
    Ruscetti, F. W.
    Kim, S. J.

  2. Author Address

    Kim SJ NCI CHEMOPREVENT LAB DIV BASIC SCI BLDG 41 RM B1106 BETHESDA, MD 20892 USA NCI CHEMOPREVENT LAB DIV BASIC SCI BETHESDA, MD 20892 USA NCI FREDERICK CANC RES & DEV CTR LAB LEUKOCYTE BIOL DIV BASIC SCI FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR INTRAMURAL RES SUPPORT PROGRAM SAIC FREDERICK FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Biological Chemistry
    1. 272
    2. 14
    3. Pages: 8905-8911
  4. Type of Article: Article
  1. Abstract:

    The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate ESF-1-mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription. [References: 62]

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