Skip NavigationSkip to Content
Return Return to Search Results

Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies

  1. Author:
    Murphy, W. J.
    Koh, C. Y.
    Raziuddin, A.
    Bennett, M.
    Longo, D. L.

  2. Author Address

    NCI, Intramural Res Support Program, SAIC, Bldg 567, Room 210, Frederick, MD 21702 USA. NCI, Intramural Res Support Program, SAIC, Frederick, MD 21702 USA. NCI, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21701 USA. Univ Texas, SW Med Ctr, Dallas, TX 75230 USA. NIA, Gerontol Res Ctr, Baltimore, MD 21224 USA. Murphy WJ NCI, Intramural Res Support Program, SAIC, Bldg 567, Room 210, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Immunological Reviews
    1. 181
    2. Pages: 279-289
  4. Type of Article: Review
  1. Abstract:

    Natural killer (NK) cells mediate acute rejection of bone marrow, but not solid tissue, allografts in lethally irradiated mice. Precisely how and why this rejection occurs is still unclear. In allogeneic bone marrow transplantation (BMT), a spectrum of results is possible; one result can be marrow graft failure due to host rejection of the graft by NK and T cells and, at the opposite spectrum, the occurrence of graft-versus- host disease (GVHD). Donor NK cells, however, appear capable of improving donor engraftment without giving rise to GVHD and thus may be of use as an immunotherapy following BMT. As NK- cell inhibitory receptors play a role in bone marrow cell rejection, these same inhibitory receptors may also affect NK responses towards tumor cells. It has been demonstrated that blocking the interaction of inhibitory receptors with MHC determinants on tumor cells can result in greater antitumor effects. Thus, NK cells are capable of mediating both positive and negative effects during BMT depending on whether they are of host versus donor origin and their state of activation. Understanding their role in BMT provides insights as to their physiological roles and points the way to potential clinical uses.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel