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Recombineering: A powerful new tool for mouse functional genomics

  1. Author:
    Copeland, N. G.
    Jenkins, N. A.
    Court, D. L.

  2. Author Address

    NCI, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA. NCI, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA. NCI, Ctr Canc Res, Gene Regulat & Chromosome Biol Lab, Frederick, MD 21702 USA. Copeland NG NCI, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Nature Reviews Genetics
    1. 2
    2. 10
    3. Pages: 769-779
  4. Type of Article: Review
  1. Abstract:

    Highly efficient phage-based Escherichia coli homologous recombination systems have recently been developed that enable genomic DNA in bacterial artificial chromosomes to be modified and subcloned, without the need for restriction enzymes or DNA ligases. This new form of chromosome engineering, termed recombinogenic engineering or recombineering, is efficient and greatly decreases the time it takes to create transgenic mouse models by traditional means, Recombineering also facilitates many kinds of genomic experiment that have otherwise been difficult to carry out, and should enhance functional genomic studies by providing better mouse models and a more refined genetic analysis of the mouse genome.

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