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Conditional control of gene expression in the mouse

  1. Author:
    Lewandoski, M.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Sect Genet Vertebrate Dev, Lab Canc & Dev Biol, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Sect Genet Vertebrate Dev, Lab Canc & Dev Biol, Frederick, MD 21702 USA. Lewandoski M NCI, Frederick Canc Res & Dev Ctr, Sect Genet Vertebrate Dev, Lab Canc & Dev Biol, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Nature Reviews Genetics
    1. 2
    2. 10
    3. Pages: 743-755
  4. Type of Article: Review
  1. Abstract:

    One of the most powerful tools that the molecular biology revolution has given us is the ability to turn genes on and off at our discretion. In the mouse, this has been accomplished by using binary systems in which gene expression is dependent on the interaction of two components, resulting in either transcriptional transactivation or DNA recombination. During recent years, these systems have been used to analyse complex and multi-staged biological processes, such as embryogenesis and cancer, with unprecedented precision. Here, I review these systems and discuss certain studies that exemplify the advantages and limitations of each system.

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