Hiv Infection Induces Changes in Cd4(+) T-Cell Phenotype and Depletions Within the Cd4(+) T-Cell Repertoire That Are Not Immediately Restored By Antiviral or Immune-Based Therapies

Author:

Connors, M.

Kovacs, J. A.

Krevat, S.

Geabanacloche, J. C.

Sneller, M. C.

Flanigan, M.

Metcalf, J. A.

Walker, R. E.

Falloon, J.

Baseler, M.

Stevens, R.

Feuerstein, I.

Masur, H.

Lane, H. C.
Author Address

Lane HC NIAID IMMUNOREGULAT LAB NIH BLDG 10 ROOM 11B-13 10 CTR DR BETHESDA, MD 20892 USA NIAID IMMUNOREGULAT LAB NIH BETHESDA, MD 20892 USA NIH CTR CLIN DEPT CRIT CARE MED BETHESDA, MD 20892 USA CLIN PUERTA DE HIERREO SERV MED INTERNA 1 MADRID SPAIN NCI FREDERICK CANC RES & DEV CTR SCI APPLICAT INT CORP FREDERICK, MD 21702 USA

Abstract:

Changes in CD4(+) T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4(+) T cells was noted as disease progressed. Following protease inhibitor therapy, naive CD4(+) T cells increased only if they were present before initiation of therapy. Disruptions of the CD4(+) TCR repertoire were most prevalent in patients with the lowest CD4(+) T-cell counts. Antiviral or IL-12 therapy-induced increases in CD4(+) T-cell counts led to only minor changes in previously disrupted repertoires. Thus, CD4(+) T-cell death mediated by HIV-1 infection may result in a preferential decline in the number of naive CD4(+) T cells and disruptions of the CD4(+) T-cell repertoire that are not immediately corrected by antiviral or immune-based therapies. [References: 41]

See More

Author Address