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Susceptibility to psoriatic arthritis: Influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles

  1. Author:
    Martin, M. P.
    Nelson, G.
    Lee, J. H.
    Pellett, F.
    Gao, X. J.
    Wade, J.
    Wilson, M. J.
    Trowsdale, J.
    Gladman, D.
    Carrington, M.

  2. Author Address

    NCI, Basic Res Program, SAIC Frederick, POB B, Frederick, MD 21702 USA NCI, Basic Res Program, SAIC Frederick, Frederick, MD 21702 USA NCI, Lab Genom Divers, Frederick, MD 21702 USA Toronto Western Hosp, Toronto Western Res Inst, Toronto, ON M5T 2S8, Canada Toronto Western Hosp, Ctr Prognosis Studies Rheumat Dis, Toronto, ON M5T 2S8, Canada Univ Hlth Network, Reg HLA Lab, Toronto, ON, Canada Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England Carrington M NCI, Basic Res Program, SAIC Frederick, POB B, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Journal of Immunology
    1. 169
    2. 6
    3. Pages: 2818-2822
  4. Type of Article: Article
  1. Abstract:

    NK cell activity is partially controlled through interactions between killer Ig-like receptors (KIR) on NK cells and their respective HLA class I ligands. Independent segregation of HLA and KIR genes, along with KIR specificity for particular HLA allo-types, raises the possibility that any given individual may express KIR molecules for which no ligand is present. Inhibitory receptor genes KIR2DL2/3 and KIR2DL1 were present in nearly all subjects sampled in this study, whereas their respective activating homologs, KIR2DS2 and KIR2DS1, are each present in about half of the subjects. In this work we report that subjects with activating KIR2DS1 and/or KIR2DS2 genes are susceptible to developing psoriatic arthritis, but only when HLA ligands for their homologous inhibitory receptors, KIR2DL1 and KIR2DL2/3, are missing. Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK (and/or 1) cell activation mediated through activating receptors, thereby contributing to pathogenesis of psoriatic arthritis.

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