Skip NavigationSkip to Content
Return Return to Search Results

Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

  1. Author:
    Wang, S. S.
    Hildesheim, A.
    Gao, X. J.
    Schiffman, M.
    Herrero, R.
    Bratti, M. C.
    Sherman, M. E.
    Barnes, W. A.
    Greenberg, M. D.
    McGowan, L.
    Mortel, R.
    Schwartz, P. E.
    Zaino, R. J.
    Glass, A. G.
    Burk, R. D.
    Karacki, P.
    Carrington, M.

  2. Author Address

    NCI, Interdisciplinary Studies Sect, Environm Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS MSC 7234, Bethesda, MD 20892 USA NCI, Interdisciplinary Studies Sect, Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21701 USA Johns Hopkins Univ, Sch Med, Baltimore, MD USA George Washington Univ, Vincent T Lombardi Canc Res Ctr, Washington, DC USA George Washington Univ, Div Gynecol Oncol, Washington, DC USA Univ Penn, Grad Hosp, Philadelphia, PA 19104 USA Penn State Univ Hosp, Milton S Hershey Med Ctr, Hershey, PA 17033 USA Yale Univ, Sch Med, New Haven, CT USA Kaiser Fdn, Inst Res, Oakland, CA USA Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Epidemiol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Social Med, Bronx, NY 10467 USA Proyecto Epidemiol, Guanacaste, Costa Rica Wang SS NCI, Interdisciplinary Studies Sect, Environm Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS MSC 7234, Bethesda, MD 20892 USA
    1. Year: 2002
  2. Journal: Journal of Infectious Diseases
    1. 186
    2. 5
    3. Pages: 598-605
  4. Type of Article: Article
  1. Abstract:

    To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were cytologically normal (control subjects; n=681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel