Skip NavigationSkip to Content
Return Return to Search Results

Role of the autocrine chemokines MIP-1 alpha and MIP-1 beta in the metastatic behavior of murine T cell lymphoma

  1. Author:
    Menten, P.
    Saccani, A.
    Dillen, C.
    Wuyts, A.
    Struyf, S.
    Proost, P.
    Mantovani, A.
    Wang, J. M.
    Van Damme, J.

  2. Author Address

    Catholic Univ Louvain, Rega Inst Med Res, Lab Mol Immunol, Minderbroedersstr 10, B-3000 Louvain, Belgium Catholic Univ Louvain, Rega Inst Med Res, Lab Mol Immunol, B-3000 Louvain, Belgium Ist Ric Farmacol Mario Negri, Milan, Italy NCI, NIH, Frederick, MD 21701 USA Van Damme J Catholic Univ Louvain, Rega Inst Med Res, Lab Mol Immunol, Minderbroedersstr 10, B-3000 Louvain, Belgium
    1. Year: 2002
  2. Journal: Journal of Leukocyte Biology
    1. 72
    2. 4
    3. Pages: 780-789
  4. Type of Article: Article
  1. Abstract:

    The ESb-MP T-cell line is a highly malignant murine lymphoma, which preferentially metastasizes toward the kidney. This could be a result of the local production of monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T expressed and secreted (RANTES), which are chemotactic for ESh- MP cells. Here, we demonstrate that ESb-MP cells are already responsive to the chemotactic activity of macrophage inflammatory protein-lot (MIP-1alpha) and MIP-1beta from 1 ng/ml onward. Moreover, upon stimulation with lipopolysaccharide (LPS) or virus, ESb-MP cells themselves produce significant amounts of MIP-1 (similar to200 ng/ml). Indeed, the major autocrine chemoattractants, isolated from ESb-MP cells, were intact MIP-1alpha and MIP-1beta. Pretreatment with LPS or addition of MIP-1 inhibited the in vitro migration of ESh-MP cells toward various chemokines. Moreover, compared with untreated lymphoma cells, LPS-treated cells produced significantly less metastasis in mice. The results represented here suggest that the role of chemokines in attracting tumor cells at secondary sites depends on a balance between autocrine-produced and tissue-derived chemokines. This delicate balance should be considered in the design of antichemokine strategies in different tumor types.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel