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Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma

  1. Author:
    Ling, B.
    Veazey, R. S.
    Penedo, C.
    Xu, K.
    Lifson, J. D.
    Marx, P. A.

  2. Author Address

    Tulane Univ, Tulane Natl Primate Res Ctr, Hlth Sci Ctr, 18703 3 Rivers Rd, Covington, LA 70433 USA Tulane Univ, Tulane Natl Primate Res Ctr, Hlth Sci Ctr, Covington, LA 70433 USA Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10021 USA Univ Calif Davis, Vet Genet Lab, Davis, CA 95616 USA NCI, Frederick Canc Res & Dev Ctr, AIDS Vaccine Program, Frederick, MD USA Marx PA Tulane Univ, Tulane Natl Primate Res Ctr, Hlth Sci Ctr, 18703 3 Rivers Rd, Covington, LA 70433 USA
    1. Year: 2002
  2. Journal: Journal of Medical Primatology
    1. 31
    2. 4-5
    3. Pages: 154-163
  4. Type of Article: Article
  1. Abstract:

    Two subspecies of rhesus (Rh) macaques, the Chinese (Ch) and Indian (Ind) subspecies were infected intravenously with 100TCID(50) SIVmac239. CD4+, CD8+ T cells, plasma viral loads, depletion of intestinal lymphocytes with memory phenotype, humoral immune responses and clinical courses were monitored for 600 days. The pathogenesis of SIVmac was also compared with primary human immunodeficiency virus (HIV) infection of humans. Plasma viral loads in Ch Rh were lower in the acute and chronic phases compared with Ind Rh. SIVmac pathogenesis in Ch Rh was closer to virus loads in untreated HIV infected humans. Ch Rh had higher CD4/CD8 ratios, stronger antibody responses and interestingly, less depletion of intestinal memory CCR5+ CD4+ T lymphocytes compared with Ind Rh. One Ch Rh developed B cell origin lymphoma at 570 days post-infection, the first such report in this subspecies. Three of four Ind Rh developed AIDS within 6 months. The findings indicate that Ch Rh are more resistant to SIVmac pathogenesis compared with Ind Rh and that Ch Rh paralleled HIV-1 infections in untreated adult humans. The SIVmac infected Ch Rh subspecies are an acceptable model for HIV/AIDS.

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