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Mistargeting hippocampal axons by expression of a truncated Eph receptor

  1. Author:
    Yue, Y.
    Chen, Z. Y.
    Gale, N. W.
    Blair-Flynn, J.
    Hu, T. J.
    Yue, X.
    Cooper, M.
    Crockett, D. P.
    Yancopoulos, G. D.
    Tessarollo, L.
    Zhou, R. P.

  2. Author Address

    Rutgers State Univ, Coll Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA Rutgers State Univ, Coll Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA NCI, Frederick Canc Res & Dev Ctr, Neural Dev Grp, Mouse Canc Genet Program, Frederick, MD 21701 USA Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA Zhou RP Rutgers State Univ, Coll Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA
    1. Year: 2002
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 99
    2. 16
    3. Pages: 10777-10782
  4. Type of Article: Article
  1. Abstract:

    Topographic mapping of axon terminals is a general principle of neural architecture that underlies the interconnections among many neural structures. The Eph family tyrosine kinase receptors and their ligands, the ephrins, have been implicated in the formation of topographic projection maps. We show that multiple Eph receptors and ligands are expressed in the hippocampus and its major subcortical projection target, the lateral septum, and that expression of a truncated Eph receptor in the mouse brain results in a pronounced alteration of the hippocamposeptal topographic map. Our observations provide strong support for a critical role of Eph family guidance factors in regulating ontogeny of hippocampal projections.

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