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Bethesda proposals for classification of lymphoid neoplasms in mice

  1. Author:
    Morse, H. C.
    Anver, M. R.
    Fredrickson, T. N.
    Haines, D. C.
    Harris, A. W.
    Harris, N. L.
    Jaffe, E. S.
    Kogan, S. C.
    MacLennan, I. C. M.
    Pattengale, P. K.
    Ward, J. M.

  2. Author Address

    7 Ctr Dr,Rm 7-304,MSC 0760, Bethesda, MD 20892 USA NIAID, Immunopathol Lab, NIH, Bethesda, MD 20892 USA NCI, Hematopathol Sect, Pathol Lab, NIH, Bethesda, MD 20892 USA NCI, Pathol Histotechnol Lab, SAIC Frederick, NIH, Frederick, MD 21701 USA NCI, Vet & Tumor Pathl Sect, Ctr Canc Res, NIH, Frederick, MD 21701 USA Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA Univ Birmingham, Sch Med, Birmingham, W Midlands, England Morse HC 7 Ctr Dr,Rm 7-304,MSC 0760, Bethesda, MD 20892 USA
    1. Year: 2002
  2. Journal: Blood
    1. 100
    2. 1
    3. Pages: 246-258
  4. Type of Article: Article
  1. Abstract:

    A consensus system for classification of mouse lymphoid neoplasms according to their histopathologic and genetic features has been an elusive target for investigators involved in understanding the pathogenesis of spontaneous cancers or modeling human hematopoietic diseases in mice. An international panel of scientists with expertise in mouse and human hematopathology joined with the hematopathology subcommittee of the Mouse Models for Human Cancers Consortium to develop criteria for definition and classification of these diseases together with a standardized nomenclature. The fundamental elements contributing to the scheme are clinical features, morphology, immunophenotype, and genetic characteristics. The resulting classification has numerous parallels to the World Health Organization classification of human lymphoid tumors while recognizing differences that may be species specific. The classification should facilitate communications about mouse models of human lymphoid diseases.

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