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Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica

  1. Author:
    Hisada, M.
    Maloney, E. M.
    Sawada, T.
    Miley, W. J.
    Palmer, P.
    Hanchard, B.
    Goedert, J. J.
    Manns, A.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS-8008, Rockville, MD 20852 USA NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA Sci Applicat Int Corp, HIV Vaccine Program, Frederick, MD USA Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 30026, Japan Univ W Indies, Kingston 7, Jamaica Hisada M NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS-8008, Rockville, MD 20852 USA
    1. Year: 2002
  2. Journal: Clinical Infectious Diseases
    1. 34
    2. 12
    3. Pages: 1551-1557
  4. Type of Article: Article
  1. Abstract:

    In a prospective study involving 150 mothers and their offspring in Jamaica, we examined maternal viral factors associated with the risk of transmission of human T lymphotropic virus type 1 (HTLV-1). Overall, the incidence of HTLV-1 infection among children was 8.3 occurrences per 1000 person-months. A higher maternal provirus level (odds ratio [OR], 1.9 per quartile) and a higher HTLV-1 antibody titer (OR, 2.2 per quartile) were independently associated with transmission to children, whereas the presence of anti-Tax antibody was not. Higher maternal antibody titers also were associated with older age at infection among children who were breast-fed for less than or equal to12 months, which suggests that passively transferred maternal antibodies confer protection against infection while they persist. These data imply that mothers who have high provirus loads should be encouraged not to breast-feed. Alternatively, the successful reduction of maternal provirus loads or maintenance of passive antibody levels in infants during breast-feeding may lower the risk of transmission.

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