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BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary

  1. Author:
    Bramblett, D. E.
    Copeland, N. G.
    Jenkins, N. A.
    Tsai, M. J.

  2. Author Address

    Baylor Coll Med, Dept Mol & Cellular Biol, 1 Baylor Plaza, Houston, TX 77030 USA. Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA. Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA. NCI, Mouse Canc Genet Program, Frederick, MD 21702 USA. Bramblett DE Baylor Coll Med, Dept Mol & Cellular Biol, 1 Baylor Plaza, Houston, TX 77030 USA.
    1. Year: 2002
  2. Journal: Genomics
    1. 79
    2. 3
    3. Pages: 402-412
  4. Type of Article: Article
  1. Abstract:

    We have cloned a basic helix-loop-helix (bHLH) factor gene, Bhlhb4, from a mouse P-cell line. Fluorescence in situ hybridization (FISH) and genetic mapping place Bhlhb4 at the telomeric end of mouse chromosome 2 (H3-H4), syntenic to human chromosome 20q13. Based on phylogenetic analysis, BHLHB4 belongs to a new subgroup of bHLH factors including at least four previously identified mouse bHLH factors: BHLHB5, MIST1, OLIG1, OLIG2, and OLIG3. In the developing nervous system, Bhlhb4 was found to mark the dimesencephalic boundary, suggesting that Bhlhb4 may have a role in diencephalic regionalization. In the pancreas, Bhlhb4 is expressed in a transient fashion that suggests a role in the pancreatic endocrine cell lineage. Transfection experiments show that BHLHB4 can repress transcriptional activation mediated through the pancreatic p-cell specific insulin promoter enhancer RIPE3. Together, these data suggest that BHLHB4 may modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.

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