Skip NavigationSkip to Content
Return Return to Search Results

Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis

  1. Author:
    Tam, W.
    Hughes, S. H.
    Hayward, W. S.
    Besmer, P.

  2. Author Address

    Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Pathol, K- 508,25 E 68th St, New York, NY 10021 USA Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Pathol, New York, NY 10021 USA Cornell Univ, JOan & Sanford I Weill Med Coll, Grad Program Mol Biol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Program Mol Biol, New York, NY 10021 USA NCI, ABL Basic Res Program, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA Tam W Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Pathol, K-508,25 E 68th St, New York, NY 10021 USA
    1. Year: 2002
  2. Journal: Journal of Virology
    1. 76
    2. 9
    3. Pages: 4275-4286
  4. Type of Article: Article
  1. Abstract:

    bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis. It lacks an extensive open reading frame and is believed to function as an untranslated RNA (W. Tam, Gene 274:157-167, 2001; W. Tam, D. Ben-Yehuda, and W. S. Hayward, Mol. Cell. Biol. 17:1490-1502, 1997). The oncogenic potential of bic, particularly its ability to cooperate with c-myc in oncogenesis, was tested directly by expressing c-myc and bic, either singly or in pairwise combination, in cultured chicken embryo fibroblasts (CEFs) and in chickens using replication- competent retrovirus vectors. Coexpression of c-myc and bic in CEFs caused growth enhancement of cells. Most importantly, chick oncogenicity assays demonstrated that bic can cooperate with c-myc in lymphomagenesis and erythroleukemogenesis. The present study provides direct evidence for the involvement of untranslated RNAs in oncogenesis and provides further support for the role of noncoding RNAs as riboregulators.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel