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The discovery of thiazole-4-carboxamide adenine dinucleotide (TAD) and a recent synthetic approach for the construction of a hydrolytically resistant surrogate

  1. Author:
    Marquez, V. E.

  2. Author Address

    Marquez VE NCI, NIH, Med Chem Lab, Ctr Canc Res, Bldg 376,Boyles St,Room 104,POB B, Ft Detrick, MD 21702 USA
    1. Year: 2003
  2. Book Title: Inosine Monophosphate Dehydrogenase: A Major Therapeutic Target
  3. Series Title: Acs Symposium Series
    1. 839
    2. Pages: 198-210
  5. Type of Work: Review
  1. Abstract:

    A short account of the mechanism of action of the oncolytic nucleoside, tiazofurin, and the discovery of its active metabolite, TAD, is described. The chapter also includes a brief history of the early chemical approaches used for the synthesis of TAD and other analogues, including the phosphodiesterase-resistant beta-methylene TAD phosphonate. A new synthetic approach to the latter compound is highlighted as a viable way to obtain this class of compounds in larger quantities. U.S. government work. Published 2003 American Chemical Society.

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