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Human Tnf Receptor-Associated Factor 5 (Traf5) - Cdna Cloning, Expression and Assignment of the Traf5 Gene to Chromosome 1q32

  1. Author:
    Nakano, H.
    Shindo, M.
    Yamada, K.
    Yoshida, M. C.
    Santee, S. M.
    Ware, C. F.
    Jenkins, N. A.
    Gilbert, D. J.
    Yagita, H.
    Copeland, N. G.
    Okumura, K.

  2. Author Address

    Nakano H JUNTENDO UNIV SCH MED DEPT IMMUNOL BUNKYO KU 2-1-1 HONGO TOKYO 113 JAPAN LA JOLLA INST ALLERGY & IMMUNOL DIV MOL IMMUNOL LA JOLLA, CA 92121 USA HOKKAIDO UNIV GRAD SCH ENVIRONM EARTH SCI DIV BIOSCI CYTOGENET LAB SAPPORO HOKKAIDO 060 JAPAN NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MAMMALIAN GENET LAB FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Genomics
    1. 42
    2. 1
    3. Pages: 26-32
  4. Type of Article: Article
  1. Abstract:

    Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are signal transducers for members of the TNF receptor superfamily. We previously identified murine TRAF5 (mTRAF5) and showed that it specifically interacts with the lymphotoxin-beta receptor (LT-beta R) and activates the transcription factor NF-kappa B. Here we have cloned the human TRAF5 homologue (hTRAF5) by cross hybridization with mTRAF5 cDNA. hTRAF5 cDNA is composed of 2894 nucleotides with a 557-amino-acid open reading frame that exhibits 77.5 and 80% identity to mTRAF5 at the nucleotide and amino acid levels, respectively. Northern blot analysis revealed that hTRAF5 mRNA is expressed in all visceral organs. Western blotting revealed that hTRAF5 protein was abundantly expressed in the human follicular dentritic cell line, FDC1, and to a much lesser degree in several tumor cell lines. Interspecific backcross mapping revealed that Traf5 is located in the distal region of mouse chromosome 1, which shares a region of homology with human chromosome Iq. Fluorescence in situ hybridization confirmed regional localization to human chromosome 1q32. (C) 1997 Academic Press. [References: 44]

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