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Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the TL10 promoter-592 C/C genotype

  1. Author:
    Breen, E. C.
    Boscardin, W. J.
    Detels, R.
    Jacobson, L. P.
    Smith, M. W.
    O'Brien, S. J.
    Chmiel, J. S.
    Rinaldo, C. R.
    Lai, S. H.
    Martinez-Maza, O.

  2. Author Address

    Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, CHS 27-139, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA Sci Applicat Int Corp, Intramural Res Support Program, Ft Detrick, MD 21702 USA Natl Canc Inst Frederick, Lab Genom Divers, Ft Detrick, MD 21702 USA Northwestern Univ, Sch Med, Dept Prevent Med, Chicago, IL 60611 USA Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA Breen EC Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, CHS 27-139, Los Angeles, CA 90095 USA
    1. Year: 2003
  2. Journal: Clinical Immunology
    1. 109
    2. 2
    3. Pages: 119-129
  4. Type of Article: Article
  1. Abstract:

    Interleukin-10 (IL10) may contribute to the development of non- Hodgkin's B cell lymphoma, especially in the context of acquired immunodeficiency syndrome (AIDS), where lymphoma incidence is greatly increased. Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61, 26%) compared to CD4-matched AIDS controls (5%, P = 0.004), or to HIV-infected (2%, P = 0.002) or HIV uninfected subjects (0%, P = 0.0003). In longitudinal studies, detectable IL10 occurred at times closest to but preceding lymphoma diagnosis (P = 0.01). In an independent genetic analysis of single-nucleotide polymorphisms within the promoter region of the IL10 gene in 1157 MACS subjects, a high IL10-expressing genotype (-592 C/C) was overrepresented among lymphoma subjects (P = 0.009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma. (C) 2003 Elsevier Inc. All rights reserved.

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