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Molecular flip-flops formed by overlapping Fis sites

  1. Author:
    Hengen, P. N.
    Lyakhov, I. G.
    Stewart, L. E.
    Schneider, T. D.

  2. Author Address

    NCI, Intramural Res Support Program, SAIC, POB B,Bldg 469,Room 144, Frederick, MD 21702 USA NCI, Intramural Res Support Program, SAIC, Frederick, MD 21702 USA NCI, Lab Expt & Computat Biol, Frederick, MD 21702 USA Schneider TD NCI, Intramural Res Support Program, SAIC, POB B,Bldg 469,Room 144, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Nucleic Acids Research
    1. 31
    2. 22
    3. Pages: 6663-6673
  4. Type of Article: Article
  1. Abstract:

    The DNA-binding protein Fis frequently uses pairs of sites 7 or 11 base pairs (bp) apart. Two overlapping Fis sites separated by 11 bp are found in the Escherichia coli origin of chromosomal replication. Only one of these sites is bound by Fis at a time, so the structure is a molecular flip-flop that could direct alternative firing of replication complexes in opposite directions. Alternatively, the flip-flop could represent part of an on-off switch for replication. Because they can be used to create precise switched states, molecular flip-flops could be used as the basis of a novel molecular computer.

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