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Plants as a source of anti-cancer and anti-HIV agents

  1. Author:
    Cragg, G. M.
    Newman, D. J.

  2. Author Address

    NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diagnosis, POB B, Ft Detrick, MD 21702 USA NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diagnosis, Ft Detrick, MD 21702 USA Cragg GM NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diagnosis, POB B, Ft Detrick, MD 21702 USA
    1. Year: 2003
  2. Journal: Annals of Applied Biology
    1. 143
    2. 2
    3. Pages: 127-133
  4. Type of Article: Article
  1. Abstract:

    Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, and paclitaxel (Taxol(R)). Several promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and Combretastatin A4 phosphate. Recently, plants have yielded several agents showing anti-AIDS activity, and one of these, (+)-calanolide A, is in clinical development.

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