Skip NavigationSkip to Content
Return Return to Search Results

Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila

  1. Author:
    Chen, X.
    Oh, S. W.
    Zheng, Z. Y.
    Chen, H. W.
    Shin, H. H.
    Hou, S. X.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Immunobiol Lab, NIH, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Immunobiol Lab, NIH, Frederick, MD 21702 USA Hou SX NCI, Frederick Canc Res & Dev Ctr, Immunobiol Lab, NIH, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Developmental Cell
    1. 4
    2. 2
    3. Pages: 179-190
  4. Type of Article: Article
  1. Abstract:

    The JAK/STAT signal transduction pathway regulates many developmental processes in Drosophila. However, the functional mechanism of this pathway is poorly understood. In this report, we identify the Drosophila cyclin-dependent kinase 4 (Cdk4), which exhibits embryonic mutant phenotypes identical to those in the Hopscotch/JAK kinase and stat92E/STAT mutations. Specific genetic interactions between Cdk4 and hop mutations suggest that Cdk4 functions downstream of the HOP tyrosine kinase. We further show that Cyclin D-Cdk4 (as well as Cyclin E-Cdk2) binds and regulates STAT92E protein stability. STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel