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Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene

  1. Author:
    Kickhoefer, V. A.
    Emre, N.
    Stephen, A. G.
    Poderycki, M. J.
    Rome, L. H.

  2. Author Address

    Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, 10833 Le Conte Ave,33-131 CHS Mail Code 173717, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Frederick, MD 21702 USA Kickhoefer VA Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, 10833 Le Conte Ave,33-131 CHS Mail Code 173717, Los Angeles, CA 90095 USA
    1. Year: 2003
  2. Journal: Gene
    1. 309
    2. 2
    3. Pages: 65-70
  4. Type of Article: Article
  1. Abstract:

    Vault RNA (vRNA) genes have been cloned from several vertebrates including rat, mouse, and humans. Their copy numbers vary, as does the length of the encoded RNA. We have determined that the mouse genome contains two vRNA genes; one is expressed the other is a pseudogene. In vitro transcription of the rat vRNA gene by RNA polymerase III has previously been shown to be dependent on a combination of both external and internal promoter sequence elements. By comparing the upstream regions of the vertebrate vRNA genes, a 25 bp conserved sequence and a TATA box can be identified. Furthermore, the unique arrangement of the internal promoter boxes (one A and two B boxes) is conserved in the expressed human vRNA genes even though a new RNA polymerase III termination sequence has evolved between the two B boxes. (C) 2003 Elsevier Science B.V. All rights reserved.

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